Hydrochloric Acid → 2-Amino-1-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-ethanone hydrochloride

HRID 1178148Notes

Reaction equation

HRID 1178148 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:28])[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=2[Br:27])[CH2:14][CH2:13]1)=[O:11])(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:28])[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=2[Br:27])[CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59559647HCID 59559647, compound

Product 1

HCID 669531722-Amino-1-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-ethanone hydrochlorideYield 87.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Saturated HCl in 1,4-dioxane (1.0 ml) was added to a stirred solution of {2-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester (375 mg, 0.82 mmol) in 1,4-dioxane (1.0 mL) at room temperature and the resulting mixture was stirred for 15 minutes. The mixture was then concentrated and the product obtained was washed with diethyl ether to afford 2-amino-1-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-ethanone hydrochloride in 87.8% yield. LC-MS purity: 83.28%

Workup

  1. concentrationThe mixture was then concentrated
  2. customthe product obtained
  3. washwas washed with diethyl ether

Sources & evidence

ORD record
ord-05d3191411b04c21982bff635b3bae16
Source dataset
uspto-grants-2010_11
Patent number
US07842696B2

Reaction notes

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