Hydrochloric Acid → HCID 66953488, compound

HRID 1178151Notes

Reaction equation

HRID 1178151 reaction equation
Cl.C(OC(=O)[NH:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:27])[C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[Cl:26])[CH2:14][CH2:13]1)=[O:11])(C)(C)C>O1CCOCC1>[ClH:25].[NH2:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:27])[C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[Cl:26])[CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59559606{2-[4-(2,5-Dichloro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 66953488HCID 66953488, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Saturated HCl in 1,4-dioxane (1.0 mL) was added to a stirred solution of {2-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester (280 mg, 0.67 mmol) in 1,4-dioxane (1.0 mL) at ambient temperature. The mixture was stirred at room temperature for 15 minutes then concentrated. The resulting solid was washed with diethyl ether to afford 2-amino-1-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-ethanone hydrochloride as a solid in 78.9% yield. LC-MS purity: 94.019%

Workup

  1. concentrationthen concentrated
  2. washThe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-616c294025684ca7a72a3bb8aac8c077
Source dataset
uspto-grants-2010_11
Patent number
US07842696B2

Reaction notes

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