Sodium methanethiolate → HCID 22320427, compound

HRID 1178285Notes

Reaction equation

HRID 1178285 reaction equation
Cl[CH2:2][CH2:3][NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16].[CH3:18][S-:19].[Na+]>>[CH3:18][S:19][CH2:2][CH2:3][NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16]

Participants

3

Reactant 2

HCID 4378561Sodium methanethiolateHCID 22320469HCID 22320469, compound

Product 1

HCID 22320427HCID 22320427, compoundYield 78.9%

Procedure

Using the general method of Example 21 Part D, N-(2-chloroethyl)-3-nitroquinolin-4-amine (6.0 g, 23.84 mmol) was reacted with sodium thiomethoxide (2.11 g of 95%, 28.61 mmol) to provide 4.95 g of N-[2-(methylthio)ethyl]-3-nitroquinolin-4-amine as a dull yellow solid.

Sources & evidence

ORD record
ord-2c06f0ca7b11426f81252e1ffda81f80
Source dataset
uspto-grants-2007_10
Patent number
US07276515B2

Reaction notes

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