HCID 22320435, compound → HCID 10237336, compound

HRID 1178298Notes

Reaction equation

HRID 1178298 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:18]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[C:10]([NH2:19])[C:9]=2[N:8]=[C:7]1[CH2:20][CH3:21].[SH:22][C:23]1[N:28]=[CH:27][CH:26]=[CH:25][N:24]=1>>[CH2:20]([C:7]1[N:6]([CH2:5][CH2:4][CH2:3][CH2:2][S:22][C:23]2[N:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[C:18]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[C:10]([NH2:19])[C:9]=2[N:8]=1)[CH3:21]

Participants

3

Reactant 2

HCID 22320435HCID 22320435, compoundHCID 178418793HCID 178418793, compound

Product 1

HCID 10237336HCID 10237336, compoundYield 80.1%

Procedure

Using the general method of Example 20 Part A, 1-(chlorobutyl)-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine (1.0 g, 3.30 mmol) was reacted with 2-mercaptopyrimidine (0.59 g, 5.3 mmol) to provide 1.0 g of 2-ethyl-1-[4-(pyrimidin-2-ylthio)butyl]-1H-imidazo[4,5-c]quinolin-4-amine as an off white powder, m.p. 182-185° C.

Sources & evidence

ORD record
ord-d77e1befac2d4778b9b851de9b4761b6
Source dataset
uspto-grants-2007_10
Patent number
US07276515B2

Reaction notes

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