Trimethylsilyl iodide → HCID 131726615, compound

HRID 1178303Notes

Reaction equation

HRID 1178303 reaction equation
I[Si](C)(C)C.C(OC([NH:13][CH2:14][C:15]([O:17][C@H:18]1[C:35]([CH3:37])([CH3:36])[O:34][C:33]2[C:20](=[C:21]3[C:30](=[C:31]([O:38][CH3:39])[CH:32]=2)[C:29](=[O:40])[C:28]2[C:23](=[CH:24][CH:25]=[C:26]4[CH:44]=[CH:43][CH:42]=[CH:41][C:27]4=2)[N:22]3[CH3:45])[C@H:19]1[O:46][C:47](=[O:49])[CH3:48])=[O:16])=O)(C)(C)C>C(Cl)(Cl)Cl>[NH2:13][CH2:14][C:15]([O:17][C@H:18]1[C:35]([CH3:36])([CH3:37])[O:34][C:33]2[C:20](=[C:21]3[C:30](=[C:31]([O:38][CH3:39])[CH:32]=2)[C:29](=[O:40])[C:28]2[C:23](=[CH:24][CH:25]=[C:26]4[CH:44]=[CH:43][CH:42]=[CH:41][C:27]4=2)[N:22]3[CH3:45])[C@H:19]1[O:46][C:47](=[O:49])[CH3:48])=[O:16]

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 131726614HCID 131726614, compound

Product 1

HCID 131726615HCID 131726615, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Add 0.14 μl of iodotrimethylsilane to a solution, at ambient temperature, of 0.1 mmol of the compound of Example 11 in 1 ml of chloroform. The reaction mixture is stirred at ambient temperature for 5 minutes and then evaporated to dryness under reduced pressure. Chromatography over silica gel (dichloromethane/methanol:85/15) allows the expected product to be isolated.

Workup

  1. customat ambient temperature
  2. customevaporated to dryness under reduced pressure
  3. customto be isolated

Sources & evidence

ORD record
ord-841db867a9984ab583b4643dfd3aa5ac
Source dataset
uspto-grants-2007_10
Patent number
US07276512B2

Reaction notes

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