HCID 11998771, compound → HCID 86607427, compound

HRID 1178340Notes

Reaction equation

HRID 1178340 reaction equation
[F:1][C:2]([F:47])([F:46])[CH2:3][C:4]([N:6]([CH2:8][C@@:9]([N:36]([CH3:45])[C:37](=[O:44])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([Cl:35])[CH:29]=1)[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][C:15]2([C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:20][C:19](=[O:27])[NH:18]2)[CH2:14][CH2:13]1)[CH3:7])=[O:5].Cl.O1CCOCC1>C(Cl)(Cl)Cl>[ClH:34].[F:46][C:2]([F:1])([F:47])[CH2:3][C:4]([N:6]([CH2:8][C@@:9]([N:36]([CH3:45])[C:37](=[O:44])[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)([C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([Cl:35])[CH:29]=1)[CH2:10][CH2:11][N:12]1[CH2:13][CH2:14][C:15]2([C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:20][C:19](=[O:27])[NH:18]2)[CH2:16][CH2:17]1)[CH3:7])=[O:5]

Participants

4

Reactant 2

HCID 11998771HCID 11998771, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86607427HCID 86607427, compoundYield 168%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N-{1-(3,3,3-Trifluoro-N-methylpropanamido)-2-(S)-(3,4-dichlorophenyl)-4-[3-oxo-3,4-dihydro-2H-spiro(isoquinoline-1,4′-piperidin)-1′-yl]butan-2-yl}-N-methylbenzamide (442 mg) was dissolved in chloroform, and 4N HCl-1,4-dioxane (160 μL) was added thereto. The solvent was concentrated under reduced pressure. Ether was added to the residue, followed by filtration and drying, to thereby give the title compound (391 mg, 84.0%) as white powder.

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. additionEther was added to the residue
  3. filtrationfollowed by filtration
  4. customdrying

Sources & evidence

ORD record
ord-e7fb8d8bcba945269bbc6bcb9b515281
Source dataset
uspto-grants-2007_10
Patent number
US07276511B2

Reaction notes

Loading…