反应详情

tert-Butyl (2-oxo-1,2,3,4-tetrahydro-1,7-naphthyridine-3-yl)carbamate (Method 29, 284 mg) was dissolved in DCM (10 mL) and treated with trifluoroacetic acid (5 mL). After stirring at ambient temperature for 1 hour the reaction mixture was evaporated under reduced pressure and the residue triturated with ether (20 mL), to give a light brown solid which was collected by filtration, washed with ether and dried to give the title compound (346 mg, 82%) as a bis trifluoracetate salt.

1. customwas evaporated under reduced pressure
2. customthe residue triturated with ether (20 mL)
3. customto give a light brown solid which
4. filtrationwas collected by filtration
5. washwashed with ether
6. customdried