Triethylamine → Methyl 5-[methyl(propan-2-yl)amino]-2-[2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexane-1-carboxylate

HRID 117858Notes

Reaction equation

HRID 117858 reaction equation
[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[Cl:23][c:24]1[n:25][cH:26][n:27][c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][c:33]12.[NH2:1][CH:2]1[C:3](=[O:22])[N:4]([CH:7]2[CH:8]([C:18](=[O:19])[O:20][CH3:21])[CH2:9][CH:10]([N:13]([CH3:14])[CH:15]([CH3:16])[CH3:17])[CH2:11][CH2:12]2)[CH2:5][CH2:6]1>>[NH:1]([CH:2]1[C:3](=[O:22])[N:4]([CH:7]2[CH:8]([C:18](=[O:19])[O:20][CH3:21])[CH2:9][CH:10]([N:13]([CH3:14])[CH:15]([CH3:16])[CH3:17])[CH2:11][CH2:12]2)[CH2:5][CH2:6]1)[c:24]1[n:25][cH:26][n:27][c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][c:33]12

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 21074843Methyl 2-(3-amino-2-oxopyrrolidin-1-yl)-5-[methyl(propan-2-yl)amino]cyclohexane-1-carboxylateHCID 210750954-Chloro-6-(trifluoromethyl)quinazoline

Product 1

HCID 21074852Methyl 5-[methyl(propan-2-yl)amino]-2-[2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexane-1-carboxylate

Sources & evidence

ORD record
ord-756636576a274634b4bdf657069e91f9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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