Hydrochloric Acid → HCID 21964251, compound

HRID 1178593Notes

Reaction equation

HRID 1178593 reaction equation
[ClH:1].[NH2:2][C:3]1[S:4][C:5]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([NH:22][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:17]=2)=[C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=2)[N:7]=1>CO>[ClH:1].[NH2:2][C:3]1[S:4][C:5]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([NH:22][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:17]=2)=[C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=2)[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9952828N-[4-[2-AMINO-4-(3,5-DIMETHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]BENZAMIDE

Product 1

HCID 21964251HCID 21964251, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A 10% solution of hydrogen chloride in methanol (10 mL) was added to a suspension of N-[4-[2-amino-4-(3,5-dimethylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (0.45 g, 1.1 mmol) in methanol (30 mL) and the mixture was stirred at room temperature for 30 minutes. The solvent was distilled off and the residue was recrystallized from methanol to obtain 0.36 g (0.83 mmol, yield 73%) of the title compound.

Workup

  1. distillationThe solvent was distilled off
  2. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-7aa809ca03974210a4ae0006ac3df335
Source dataset
uspto-grants-2007_10
Patent number
US07276527B2

Reaction notes

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