Trifluoroacetic acid → HCID 69515580, compound

HRID 1178707Notes

Reaction equation

HRID 1178707 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6]([S:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[N:7][S:8][C:9]=1[NH:10]C(OC(C)(C)C)=O)=[O:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[C:6]([S:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[N:7][S:8][C:9]=1[NH2:10])=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69515471HCID 69515471, compound

Product 1

HCID 69515580HCID 69515580, compoundYield 82.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 19 (6.5 g, 15.67 mmol) is dissolved in methylene chloride (65 mL) and TFA is added (65 mL). After 16 hrs., the reaction is filtered and the solids are washed with ethyl ether. The solids are further dried in vacuo to provide 20 (4.06 g, 82%). 1H NMR (d6 DMSO): δ 7.88 (2H, br. s), 7.38 (2H, d, J=8.6 Hz), 7.32 (2H, d, J=8.6 Hz), 4.24 (2H, s), 3.69 (3H, s).

Workup

  1. filtration, the reaction is filtered
  2. washthe solids are washed with ethyl ether
  3. customThe solids are further dried in vacuo

Sources & evidence

ORD record
ord-6bb385830b16449baa7f87a5c8e892f0
Source dataset
uspto-grants-2007_10
Patent number
US07276602B2

Reaction notes

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