Indole → HCID 23118676, compound

HRID 1178727Notes

Reaction equation

HRID 1178727 reaction equation
[CH:1]1[C:14]2[C:5](=[N:6][CH:7]=[C:8]3[C:13]=2[CH:12]=[CH:11][CH:10]=[CH:9]3)[CH:4]=[CH:3][CH:2]=1.[Br:15][C:16]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:17]=1[C:18](Cl)=[O:19].[NH:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28]1>>[Br:15][C:16]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:17]=1[C:18]([N:6]1[CH:7]([C:29]2[C:30]3[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=3)[NH:27][CH:28]=2)[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]1=2)=[O:19]

Participants

4

Reactant 3

HCID 798IndoleHCID 9189PhenanthridineHCID 27816562-Bromo-5-methoxybenzoyl chloride

Product 1

HCID 23118676HCID 23118676, compound

Procedure

(2-Bromo-5-methoxy-phenyl)-[6-(1H-indol-3-yl)-6H-phenanthridin-5-yl]-methanone was prepared from phenanthridine, 2-bromo-5-methoxybenzoyl chloride, and indole according to GP 2. Yield, 30%. (+)-ESI-MS: m/z=509 [M(79Br)+H]+, 392 [M(79Br)-indole+H]+.

Workup

  1. customYield

Sources & evidence

ORD record
ord-1d9d58d7fcfa4b54ae1571a0e9858cd2
Source dataset
uspto-grants-2007_10
Patent number
US07276606B2

Reaction notes

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