Indole → HCID 68489430, compound

HRID 1178743Notes

Reaction equation

[CH:1]1[C:14]2[C:5](=[N:6][CH:7]=[C:8]3[C:13]=2[CH:12]=[CH:11][CH:10]=[CH:9]3)[CH:4]=[CH:3][CH:2]=1.Cl[C:16]([O:18][CH3:19])=[O:17].[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21]1>>[CH3:19][O:18][C:16]([N:6]1[CH:7]([C:22]2[C:23]3[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=3)[NH:20][CH:21]=2)[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]1=2)=[O:17]

Participants

Reactant 3

HCID 798Indole

HCID 6586Methyl chloroformate

HCID 9189Phenanthridine

Product 1

HCID 68489430HCID 68489430, compound

Procedure

6-(1H-Indol-3-yl)-6H-phenanthridine-5-carboxylic acid methyl ester was prepared from phenanthridine, methyl chloroformate, and indole according to GP 2. Yield, 9%. (+)-ESI-MS: m/z=355 [M+H]+, 238 [M-indole+H]+.

Workup

customYield

Sources & evidence

ORD record: ord-53955d72461f4c0d931b6e03256deb74
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07276606B2

Reaction notes

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