反应详情

To a stirred suspension of LiAlH4 (200 mg, excess) in THF at 0° C., ethyl(-1-benzofuran-3-yl)acetate (1.02 g, 5 mmol) in THF (20 mL) was added slowly. After the addition, the reaction mixture was stirred at room temperature for 1 hr and quenched with saturated NH4Cl solution. The product was extracted with chloroform and washed well with water. It was dried over anhydrous MgSO4, filtered and concentrated. The product 2-(1-benzofuran-3-yl)ethanol obtained as a white oil was pure enough to be taken to next step without further purification. Yield: 800 mg (98%); (M+H): 163.

1. additionAfter the addition
2. customquenched with saturated NH4Cl solution
3. extractionThe product was extracted with chloroform
4. washwashed well with water
5. dry with materialIt was dried over anhydrous MgSO4
6. filtrationfiltered
7. concentrationconcentrated