Trimethylsilyl iodide → HCID 68521542, compound

HRID 1178892Notes

Reaction equation

HRID 1178892 reaction equation
[C:1]([NH:4][CH:5]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[CH:15]1[CH2:21][CH:20]2[N:22](C(OCC)=O)[CH:17]([CH2:18][CH2:19]2)[CH2:16]1)[CH2:6][CH3:7])(=[O:3])[CH3:2].[I:28][Si](C)(C)C>C(Cl)Cl>[I-:28].[C:1]([NH:4][CH:5]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[CH:15]1[CH2:21][CH:20]2[NH2+:22][CH:17]([CH2:18][CH2:19]2)[CH2:16]1)[CH2:6][CH3:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 58695824HCID 58695824, compound

Product 1

HCID 68521542HCID 68521542, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of ethyl 3-{2-[1-(acetylamino)propyl]-4-chlorophenyl}-8-azabicyclo[3.2.1]octane-8-carboxylate (2-9) (0.200 g, 0.51 mmol) in DCM (5.0 mL) was added iodotrimethylsilane (0.360 mL, 2.55 mmol) slowly. The mixture was stirred at room temperature overnight. After the reaction was completed, the solvents were removed under vacuum and solid was washed with ether (2×5 mL) to give (2-10) as yellow solid.

Workup

  1. customthe solvents were removed under vacuum and solid
  2. washwas washed with ether (2×5 mL)

Sources & evidence

ORD record
ord-aaf638fc8c834041a7635206edc50b43
Source dataset
uspto-grants-2007_10
Patent number
US07276520B2

Reaction notes

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