huagongshe.com
HRID1178928

反应详情

EQUATION

反应方程式

HRID 1178928 反应方程式

REACTANTS

反应物

3
Hydrochloric Acid 分子结构式
HCID313

Hydrochloric Acid

ClH

4-Cyano-2-fluoropyridine 分子结构式
HCID12002587

4-Cyano-2-fluoropyridine

C6H3FN2

1-(2-Fluoropyridin-3-yl)methanamine--hydrogen chloride (1/1) 分子结构式
HCID67023208

1-(2-Fluoropyridin-3-yl)methanamine--hydrogen chloride (1/1)

C6H8ClFN2

PRODUCTS

产物

1
1-(2-Fluoropyridin-4-yl)methanamine--hydrogen chloride (1/1) 分子结构式
HCID66524242

1-(2-Fluoropyridin-4-yl)methanamine--hydrogen chloride (1/1)

C6H8ClFN2

收率 50%

AUXILIARIES

试剂、催化剂与溶剂

1
Palladium 分子结构式
催化剂HCID23938

Palladium

Pd

PROCEDURE

实验过程

Following a method similar to C-(2-Fluoro-pyridin-3-yl)-methylamine hydrochloride, using 2-fluoro-isonicotinonitrile (0.65 g, 5.3 mmol), concentrated HCl (1.2 mL), and 5% Pd/C (1.2 g) to give the title compound (0.43 g, 50%). MS (ES) 127.1 (M+1)+.