Ammonium Hydroxide → Oxane-4-carboxamide

HRID 1178957Notes

Reaction equation

HRID 1178957 reaction equation
C[O:2][C:3]([CH:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=O.[OH-].[NH4+:12]>>[O:8]1[CH2:9][CH2:10][CH:5]([C:3]([NH2:12])=[O:2])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 27735202H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester

Product 1

HCID 13197203Oxane-4-carboxamide

Procedure

In a 5 L flask, charge methyltetrahydropyran-4-carboxylate (500 ml, 3.75 mol) and concentrated ammonium hydroxide (1.3 L) and stir the reaction at room temperature for 48 hours. Filter the reaction and dry the white solid in a vacuum oven at 60° C. overnight to obtained 36.33 g white solid of the title compound.

Workup

  1. customthe reaction at room temperature for 48 hours
  2. filtrationFilter
  3. customthe reaction
  4. customdry the white solid in a vacuum oven at 60° C. overnight

Sources & evidence

ORD record
ord-9a9c9c32bd4142a8a3ff05af01d4572f
Source dataset
uspto-grants-2007_10
Patent number
US07276516B2

Reaction notes

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