Chlorotrimethylsilane → HCID 69337912, compound

HRID 1179073Notes

Reaction equation

HRID 1179073 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]([CH3:28])[CH:13]2[CH2:18][CH2:17][C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([N:19]([CH3:21])[CH3:20])[CH2:15][CH2:14]2)=[CH:2]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:41].Cl.[Cl:43][Si](C)(C)C>CC(=O)CC.CC(C)=O>[ClH:43].[ClH:41].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]([CH3:28])[CH:13]2[CH2:18][CH2:17][C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([N:19]([CH3:20])[CH3:21])[CH2:15][CH2:14]2)=[CH:2]1

Participants

5

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 10156333HCID 10156333, compound

Product 1

HCID 69337912HCID 69337912, compound

Reagents, catalysts & solvents 1

HCID 22381885HCID 22381885, compoundSolvent

Procedure

As described for example 66, 129 mg of the polar diastereomer of N′-[2-(1H-indol-3-yl)-ethyl]-N,N,N′-trimethyl-1-phenyl-cyclohexane-1,4-diamine were also obtained and were converted into the corresponding dihydrochloride while warm in 2-butanone/acetone (15 ml/3 ml) with chlorotrimethylsilane (121 μl) (white solid; 141 mg; m.p. 198-206° C.).

Workup

  1. customwere also obtained

Sources & evidence

ORD record
ord-dfd34d675aa94d638485eef331693edf
Source dataset
uspto-grants-2007_10
Patent number
US07276518B2

Reaction notes

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