Chlorosuccinimide → HCID 12071591, compound

HRID 1179108Notes

Reaction equation

HRID 1179108 reaction equation
[NH:1]([C:8]1[C:18](=[O:19])[C:12]2[N:13]=[C:14]([CH2:16][CH3:17])[O:15][C:11]=2[C:10](=[O:20])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:21]N1C(=O)CCC1=O>C(O)(=O)C>[NH:1]([C:8]1[C:18](=[O:19])[C:12]2[N:13]=[C:14]([CH2:16][CH3:17])[O:15][C:11]=2[C:10](=[O:20])[C:9]=1[Cl:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12071587AGN-PC-0NHP1N

Product 1

HCID 12071591HCID 12071591, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-anilino-2-ethyl-1,3-benzoxazole-4,7-dione (1 eq.) in acetic acid is treated with N-chlorosuccinimide (1.1 eq.) at ambient temperature. The reaction medium is maintained under stirring for 2 hours before being concentrated, followed by taking up in ethanol and concentrating again. The residue is purified by medium pressure chromatography on silica in order to produce a violet-coloured powder.

Workup

  1. temperatureThe reaction medium is maintained
  2. concentrationbefore being concentrated
  3. concentrationconcentrating again
  4. customThe residue is purified by medium pressure chromatography on silica in order
  5. customto produce a violet-coloured powder

Sources & evidence

ORD record
ord-7d6eccadb92f4b718d932e04646c7fd1
Source dataset
uspto-grants-2007_10
Patent number
US07279467B2

Reaction notes

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