反应详情

温度

70 °C

1 ml (7.62 mmol, 1.1 eq.) of cyclohexanoic acid chloride is added to a solution of 1.05 g (6.89 mmol) of 2,5-dimethoxyaniline in 10 ml of a mixture toluene/methanol (1/1). The reaction mixture is maintained under stirring at 70° C. for 1.5 hour, and, after returning to ambient temperature, is poured into 50 ml of water. The expected product is extracted twice with 50 ml of toluene, then washed twice with 50 ml of water. The organic phases are combined, dried over magnesium sulphate and the solvent evaporated off under reduced pressure. 1.46 g (yield=67%) of N-(2,5-dimethoxyphenyl)cyclohexanecarboxamide is obtained and used without other purification in the following stage.

1. temperatureThe reaction mixture is maintained
2. customafter returning to ambient temperature
3. extractionThe expected product is extracted twice with 50 ml of toluene
4. washwashed twice with 50 ml of water
5. dry with materialdried over magnesium sulphate
6. customthe solvent evaporated off under reduced pressure