HRID1179144

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21521

2-Bromoethyl ether

C4H8Br2O

结构：NCc1ccc(-c2c[nH]nc2-c2c[nH]c(C(=O)NC(CO)c3ccc(F)c(Cl)c3)c2)cc1Cl

HCID178509601

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(CO)c1ccc(F)c(Cl)c1)c1cc(-c2n[nH]cc2-c2ccc(CN3CCOCC3)c(Cl)c2)c[nH]1

HCID178523442

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 70 °C

PROCEDURE

实验过程

To a solution of benzyl amine 11 (0.05 mmol) in DMF (3 mL) was added TEA (0.15 mmol) and 2-bromoethyl ether (0.05 mmol). The resulting solution was stirred for 18 h at 70° C. The solvent was removed under vacuum and the crude products purified by preparatory HPLC to afford II-6 as a yellow oil.

WORKUP

后处理

customThe solvent was removed under vacuum
customthe crude products purified by preparatory HPLC
customto afford II-6 as a yellow oil

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6325cc0ef2c34e4f81d34486efa9320b
来源数据集: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07279476B2
来源说明: uspto-grants-2007_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:12][C:13]([C:15]2[NH:16][CH:17]=[C:18]([C:20]3[C:24]([C:25]4[CH:30]=[CH:29][C:28]([CH2:31][NH2:32])=[C:27]([Cl:33])[CH:26]=4)=[CH:23][NH:22][N:21]=3)[CH:19]=2)=[O:14])[CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[F:8].Br[CH2:35][CH2:36][O:37][CH2:38][CH2:39]Br>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:12][C:13]([C:15]2[NH:16][CH:17]=[C:18]([C:20]3[C:24]([C:25]4[CH:30]=[CH:29][C:28]([CH2:31][N:32]5[CH2:39][CH2:38][O:37][CH2:36][CH2:35]5)=[C:27]([Cl:33])[CH:26]=4)=[CH:23][NH:22][N:21]=3)[CH:19]=2)=[O:14])[CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[F:8]