Triethylamine → (6-Hydrazineylpyridin-3-yl)(morpholino)methanone

HRID 1179211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1179211
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[NH2:16][NH2:17].C(N(CC)CC)C>C(O)C>[NH:16]([C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1)[NH2:17]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 9321HydrazineHCID 8574994-(6-Chloropyridine-3-carbonyl)morpholine

Produkt 1

HCID 58976910(6-Hydrazineylpyridin-3-yl)(morpholino)methanoneAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone (0.649 g, 2.86 mmoles) in ethanol (6 mL) was added 0.270 uL (3.0 equivalents) of hydrazine, followed by triethylamine 438.9 uL (1.1 equivalents). The reaction was stirred overnight at 100° C. to give (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone. The reaction was filtered and then concentrated to dryness. The crude residue, (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone, weighed 0.372 g (76% yield).

Quellen und Nachweise

ORD-Eintrag
ord-86624be6b6d64413836f737ee487bf9a
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07279469B2

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