HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (6-Hydrazineylpyridin-3-yl)(morpholino)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 4-(6-Chloropyridine-3-carbonyl)morpholine | HCID 857499 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (6-Hydrazineylpyridin-3-yl)(morpholino)methanone | HCID 58976910 | 76% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone (0.649 g, 2.86 mmoles) in ethanol (6 mL) was added 0.270 uL (3.0 equivalents) of hydrazine, followed by triethylamine 438.9 uL (1.1 equivalents). The reaction was stirred overnight at 100° C. to give (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone. The reaction was filtered and then concentrated to dryness. The crude residue, (6-hydrazino-pyridin-3-yl)-morpholin-4-yl-methanone, weighed 0.372 g (76% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279469B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-86624be6b6d64413836f737ee487bf9a |
| Source note | uspto-grants-2007_10 |