HCID 58976754, compound → HCID 58976778, compound

HRID 1179242Notes

Reaction equation

HRID 1179242 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:11]([O:23][CH3:24])=[C:10]([O:25][CH3:26])[CH:9]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH3:26][O:25][C:10]1[CH:9]=[C:8]([NH2:7])[CH:13]=[C:12]([O:14][CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[C:11]=1[O:23][CH3:24]

Participants

4

Reactant 1

HCID 58976754HCID 58976754, compound

Product 1

HCID 58976778HCID 58976778, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

[3,4-Dimethoxy-5-(2-morpholin-4-yl-ethoxy)-phenyl]-carbamic acid tert-butyl ester, (97 mg, 0.24 mmol, was stirred in 1 mL DCM and 1 mL TFA. After ˜1 h, the TFA and DCM were evaporated and 2 mL sat. sodium bicarbonate solution was added. The aqueous layer was extracted with DCM which was evaporated affording 60 mg 3,4-Dimethoxy-5-(2-morpholin-4-yl-ethoxy)-phenylamine. MS ES+ 283.1

Workup

  1. customthe TFA and DCM were evaporated
  2. addition2 mL sat. sodium bicarbonate solution was added
  3. extractionThe aqueous layer was extracted with DCM which
  4. customwas evaporated

Sources & evidence

ORD record
ord-d27a3aed3f6b45ba843eedf5a64a4121
Source dataset
uspto-grants-2007_10
Patent number
US07279469B2

Reaction notes

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