HCID 619795, compound → HCID 58976855, compound

HRID 1179243Notes

Reaction equation

HRID 1179243 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]([NH:5][C:6]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:7]=1[F:15])=[O:4]>CCOC(C)=O.[Pd]>[NH2:12][C:10]1[CH:9]=[CH:8][C:7]([F:15])=[C:6]([NH:5][C:3](=[O:4])[C:2]([F:1])([F:16])[F:17])[CH:11]=1

Participants

4

Reactant 1

HCID 619795HCID 619795, compound

Product 1

HCID 58976855HCID 58976855, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The crude acetamide was dissolved in EtOAc (50 mL), shacked with 10% Pd/C (450 mg) under H2 (50 psi) for 3 h. Filtration gave an N-(5-amino-2-fluoro-phenyl)-2,2,2-trifluoro-acetamide (8.42 g).

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-2ba12375a0794c57adc09d00ea078ee1
Source dataset
uspto-grants-2007_10
Patent number
US07279469B2

Reaction notes

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