2-Hydrazinopyridine → HCID 58976311, compound

HRID 1179249Notes

Reaction equation

HRID 1179249 reaction equation
[C:1]([NH:3][C:4](=[N:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH:20]([F:22])[F:21])=[C:15]([O:23][CH:24]([CH3:26])[CH3:25])[CH:14]=1)OC1C=CC=CC=1)#[N:2].[NH:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1)[NH2:28]>CC(N(C)C)=O>[F:22][CH:20]([F:21])[O:19][C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:4]2[N:3]=[C:1]([NH2:2])[N:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)[N:28]=2)=[CH:14][C:15]=1[O:23][CH:24]([CH3:25])[CH3:26]

Participants

4

Reactant 2

HCID 786452-HydrazinopyridineHCID 86594811HCID 86594811, compound

Product 1

HCID 58976311HCID 58976311, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
220 °C

Procedure

A mixture of N-cyano-N′-(4-difluoromethoxy-3-iso-propyloxyphenyl)-O-phenylisourea (0.10 g, 0.28 mmol) and 2-hydrazino-pyridine (0.06 g, 0.56 mmol) in dimethylacetamide (3 mL) was heated in the microwave apparatus at 220° C. for 15 min. The reaction was cooled, poured into ice-water and stirred for 0.5 h. The precipitate was filtered off, washed with cold water and dried to provide the title compound (0.10 g, 97% yield) as a pale pink solid.

Workup

  1. temperatureThe reaction was cooled
  2. filtrationThe precipitate was filtered off
  3. washwashed with cold water
  4. customdried

Sources & evidence

ORD record
ord-bdcbe9d864d5418aaa8d1b6be940269a
Source dataset
uspto-grants-2007_10
Patent number
US07279469B2

Reaction notes

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