Phosphorus oxychloride → HCID 58976941, compound

HRID 1179261Notes

Reaction equation

HRID 1179261 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[N:25]=[C:15]3[NH:16][C:17](=O)[C:18]4[C:23]([N:14]3[N:13]=2)=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].P(Cl)(Cl)([Cl:28])=O>>[Cl:28][C:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:14]2[N:13]=[C:12]([NH:11][C:5]3[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:25]=[C:15]2[N:16]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 136186521HCID 136186521, compound

Product 1

HCID 58976941HCID 58976941, compound

Conditions

Temperature
90 °C

Procedure

A suspension of 2-(3,4-Dimethoxy-phenylamino)-4H-[1,2,4]triazolo[1,5-a]quinazolin-5-one (57 mg) in phosphorus oxychloride (5 mL) was heated at 90° C. for 2 h. Evaporation. The residue was suspended in dichloromethane, washed with cold sodium bicarbonate, brine and dried (Na2SO4). Filtration and concentration gave crude (5-Chloro-[1,2,4]triazolo[1,5-a]quinazolin-2-yl)-(3,4-dimethoxy-phenyl)-amine (68 mg). LC-MS: m/e=356.1 (M+H),

Workup

  1. customEvaporation
  2. washwashed with cold sodium bicarbonate, brine
  3. dry with materialdried (Na2SO4)
  4. filtrationFiltration and concentration

Sources & evidence

ORD record
ord-26fc430b6b6b489fb7d8f0e6c19366ed
Source dataset
uspto-grants-2007_10
Patent number
US07279469B2

Reaction notes

Loading…