反应详情

温度

90 °C

Benzyl 2-[(dimethylamino)sulfonyl]ethylcarbamate (8.8 g, 30.7 mmol) was suspended/dissolved in 6N HCl (75 mL) and the mixture was heated to 90° C. The solids dissolved. After 1.5 hours the reaction was cooled and extracted with ether. The aqueous layer was evaporated to give a sticky white solid. The ether layer was found to contain unreacted starting material. This was retreated with 6 N HCl at room temperature overnight. The reaction was washed with ether and the aqueous layer combined with the previously isolated product and evaporated to give a white solid.

1. dissolutionThe solids dissolved
2. temperatureAfter 1.5 hours the reaction was cooled
3. extractionextracted with ether
4. customThe aqueous layer was evaporated
5. customto give a sticky white solid
6. washThe reaction was washed with ether
7. customevaporated
8. customto give a white solid