Triethylamine → HCID 58978005, compound

HRID 1179309Notes

Reaction equation

HRID 1179309 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(Cl)Cl>[CH3:1][N:2]([S:24]([CH3:23])(=[O:26])=[O:25])[CH2:3][CH2:4][NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 10822258benzyl 2-(methylamino)ethylcarbamate

Product 1

HCID 58978005HCID 58978005, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of benzyl 2-(methylamino)ethylcarbamate (0.05 g, 0.24 mmol) in CH2Cl2 (5 mL was cooled to 6° C. and treated with triethylamine (0.1 mL, 0.72 mmol) and methanesulfonyl chloride (0.02 mL, 0.24 mmol). The reaction was warmed to room temperature and stirred overnight. The reaction was washed with 10% KHSO4, the organic layer was dried over Na2SO4, filtered and evaporated to give the product.

Workup

  1. washThe reaction was washed with 10% KHSO4
  2. dry with materialthe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated
  5. customto give the product

Sources & evidence

ORD record
ord-1f44ceecbd6d49deac0bc36acf6c1302
Source dataset
uspto-grants-2007_10
Patent number
US07279487B2

Reaction notes

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