Hydrochloric Acid → HCID 45089831, compound

Participants

Reaction Steps

In a manner similar to that described in example 2, benzyl 2-[(2-cyanopyridin-3-yl)amino]ethylcarbamate (11.9 g, 38.3 mmol) was dissolved in MeOH and treated with HCl gas and water to give the ester. The reaction was concentrated, dissolved in MeOH and adsorbed to silica gel. The product was eluted with CHCl3 saturated with NH3, the fractions were collected and evaporated to give the product as a yellow oil that crystallized upon sitting.

Provenance & Evidence