Hydrochloric Acid → HCID 45089831, compound

HRID 1179314Notes

Reaction equation

HRID 1179314 reaction equation
[C:1]([C:3]1[C:8]([NH:9][CH2:10][CH2:11][NH:12][C:13](=O)OCC2C=CC=CC=2)=[CH:7][CH:6]=[CH:5][N:4]=1)#N.Cl.[OH2:24].[CH3:25][OH:26]>>[CH3:13][NH:12][CH2:11][CH2:10][NH:9][C:8]1[C:3]([C:1]([O:26][CH3:25])=[O:24])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 69375602HCID 69375602, compound

Product 1

HCID 45089831HCID 45089831, compound

Procedure

In a manner similar to that described in example 2, benzyl 2-[(2-cyanopyridin-3-yl)amino]ethylcarbamate (11.9 g, 38.3 mmol) was dissolved in MeOH and treated with HCl gas and water to give the ester. The reaction was concentrated, dissolved in MeOH and adsorbed to silica gel. The product was eluted with CHCl3 saturated with NH3, the fractions were collected and evaporated to give the product as a yellow oil that crystallized upon sitting.

Sources & evidence

ORD record
ord-cfd8021b9f1b454d95a81a345a1d6dfc
Source dataset
uspto-grants-2007_10
Patent number
US07279487B2

Reaction notes

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