[5-(2-tert-Butoxy-2-oxoethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetic acid → tert-Butyl {2-[2-({[4-(1H-benzimidazol-2-ylamino)cyclohexyl]methyl}amino)-2-oxoethyl]-1-oxo-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acetate

Participants

Role	Name	HCID	Charge
Reactant	[5-(2-tert-Butoxy-2-oxoethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetic acid	HCID 69434194	—
Reactant	HCID 178511276	HCID 178511276	—
Product	tert-Butyl {2-[2-({[4-(1H-benzimidazol-2-ylamino)cyclohexyl]methyl}amino)-2-oxoethyl]-1-oxo-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acetate	HCID 86760556	—

Reaction Steps

Analogously to Example V, compound 3 was reacted with 0.57 g (1.8 mmol) of compound 7 and the mixture was purified; 0.5 g of white amorphous powder; ESI-MS [M+H+]: 560.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07279468B2
Source dataset	uspto-grants-2007_10
ORD ID	ord-e9976777f4164ec98c84a2d90cf5d03b
Source note	uspto-grants-2007_10