HRID1179343

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CC1CCN(CC(=O)O)C(=O)c2ccccc21

HCID69434194

未命名化合物

结构：NCCCCNc1nc2ccccc2[nH]1.O=C(O)C(F)(F)F

HCID85797825

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CC1CCN(CC(=O)NCCCCNc2nc3ccccc3[nH]2)C(=O)c2ccccc21

HCID91112216

未命名化合物

PROCEDURE

实验过程

Analogously to Example IX, compound 3 was reacted with 1.0 g (3.1 mmol) of compound 9 and the reaction product was purified by column chromatography (eluent: diethyl ether/MeOH/ammonia, 40/10/2.5), 0.78 g of white amorphous powder; ESI-MS [M+H+]: 520.

WORKUP

后处理

customthe reaction product was purified by column chromatography (eluent: diethyl ether/MeOH/ammonia, 40/10/2.5), 0.78 g of white amorphous powder

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c3784d840340426899717fca663c1026
来源数据集: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07279468B2
来源说明: uspto-grants-2007_10

反应 SMILES

[C:1]([O:5][C:6](=[O:24])[CH2:7][CH:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12](=[O:19])[N:11]([CH2:20][C:21]([OH:23])=O)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[NH:32]1[C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[N:34]=[C:33]1[NH:41][CH2:42][CH2:43][CH2:44][CH2:45][NH2:46]>>[NH:32]1[C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[N:34]=[C:33]1[NH:41][CH2:42][CH2:43][CH2:44][CH2:45][NH:46][C:21](=[O:23])[CH2:20][N:11]1[CH2:10][CH2:9][CH:8]([CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:24])[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12]1=[O:19]