HuagongsheHuagongshe Chemistry Print Report · For research reference only
[5-(2-tert-Butoxy-2-oxoethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetic acid → Tert-butyl [2-(2-{[4-(1h-benzimidazol-2-ylamino)butyl]amino}-2-oxoethyl)-1-oxo-2,3,4,5-tetrahydro-1h-2-benzazepin-5-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [5-(2-tert-Butoxy-2-oxoethyl)-1-oxo-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]acetic acid | HCID 69434194 | — |
| Reactant | n1-(1h-Benzimidazol-2-yl)butane-1,4-diamine(trifluoroacetate) | HCID 85797825 | — |
| Product | Tert-butyl [2-(2-{[4-(1h-benzimidazol-2-ylamino)butyl]amino}-2-oxoethyl)-1-oxo-2,3,4,5-tetrahydro-1h-2-benzazepin-5-yl]acetate | HCID 91112216 | — |
Reaction Steps
Analogously to Example IX, compound 3 was reacted with 1.0 g (3.1 mmol) of compound 9 and the reaction product was purified by column chromatography (eluent: diethyl ether/MeOH/ammonia, 40/10/2.5), 0.78 g of white amorphous powder; ESI-MS [M+H+]: 520.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279468B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-c3784d840340426899717fca663c1026 |
| Source note | uspto-grants-2007_10 |