Hydrochloric Acid → HCID 178525209, compound

HRID 1179344Notes

Reaction equation

HRID 1179344 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:39])[CH2:18][N:19]1[CH2:25][CH2:24][CH:23]([CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])[C:22]2[CH:34]=[CH:35][CH:36]=[CH:37][C:21]=2[C:20]1=[O:38].[ClH:40]>C(O)(=O)C.O1CCOCC1.O>[Cl-:40].[C:27]([CH2:26][CH:23]1[C:22]2[CH:34]=[CH:35][CH:36]=[CH:37][C:21]=2[C:20](=[O:38])[N:19]([CH2:18][C:17]([NH:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][NH:10][C:2]2[NH2+:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[N:1]=2)=[O:39])[CH2:25][CH2:24]1)([OH:29])=[O:28]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 86760557HCID 86760557, compound

Product 1

HCID 178525209HCID 178525209, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Analagously to Example II, the tert-butyl ester (Example XIII) in glacial acetic acid was cleaved using 4N HCl in dioxane. After stripping off the solvent, the residue was dissolved in water, clarified using active carbon and then lyophilized; 0.67 g of white amorphous residue; ESI-MS [M+H+]: 478.

Sources & evidence

ORD record
ord-74b4677fc8cc4a53b4a57c499ba33fab
Source dataset
uspto-grants-2007_10
Patent number
US07279468B2

Reaction notes

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