反应详情

To a solution of the product of Example 3 (2.4 g) in dioxane (30 mL) was added 4 N HCl in dioxane (30 mL). The resulting mixture was stirred at room temperature overnight, concentrated, and treated with 10% NaOH (50 mL). The resulting mixture was extracted with DCM (2×100 mL). The combined extracts were washed with water (30 mL) and brine (30 mL), and concentrated under reduced pressure to give the title compound as a brown-yellow oil (0.81 g).

1. concentrationconcentrated
2. additiontreated with 10% NaOH (50 mL)
3. extractionThe resulting mixture was extracted with DCM (2×100 mL)
4. washThe combined extracts were washed with water (30 mL) and brine (30 mL)
5. concentrationconcentrated under reduced pressure