Piperidine → 1-[4-(4-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-3-trifluoromethyl-benzyl]-piperidine

HRID 1179392Notes

Reaction equation

HRID 1179392 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][C:14]=3[C:21]([F:24])([F:23])[F:22])[CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:1]1([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:20]=[CH:19][C:16]([CH2:17][N:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)=[CH:15][C:14]=3[C:21]([F:24])([F:23])[F:22])[CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 589780364-(4-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-3-trifluoromethyl-benzaldehyde

Product 1

HCID 104316491-[4-(4-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-3-trifluoromethyl-benzyl]-piperidine

Procedure

Prepared from the product of Example 63 and piperidine.

Sources & evidence

ORD record
ord-af2e91482b124e438610dd3e86705bae
Source dataset
uspto-grants-2007_10
Patent number
US07279491B2

Reaction notes

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