HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[2-(trifluoromethyl)-1H-1,3-benzimidazol-1-yl]acetone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(Trifluoromethyl)-1H-benzimidazole | HCID 67560 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-[2-(trifluoromethyl)-1H-1,3-benzimidazol-1-yl]acetone | HCID 876601 | — |
Reaction Steps
4 g of 2-trifluoromethylbenzimidazole, 2.8 g of chloroacetone, 3.4 g of potassium carbonate and 0.32 g of potassium iodide are dissolved in 50 ml of acetone and boiled under reflux for 4 h. After cooling, the precipitate is filtered off, washed with acetone and dried in a vacuum. 1-(2-trifluoromethylbenzimidazol-1-yl)-propanone is thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279495B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-f6c4ccca3bb84e3188e15f37b8c41c23 |
| Source note | uspto-grants-2007_10 |