Potassium Iodide → 1-[2-(trifluoromethyl)-1H-1,3-benzimidazol-1-yl]acetone

HRID 1179427Notes

Reaction equation

HRID 1179427 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.Cl[CH2:15][C:16](=[O:18])[CH3:17].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[F:13][C:2]([F:1])([F:12])[C:3]1[N:4]([CH2:15][C:16](=[O:18])[CH3:17])[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 675602-(Trifluoromethyl)-1H-benzimidazole

Product 1

HCID 8766011-[2-(trifluoromethyl)-1H-1,3-benzimidazol-1-yl]acetone

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4 g of 2-trifluoromethylbenzimidazole, 2.8 g of chloroacetone, 3.4 g of potassium carbonate and 0.32 g of potassium iodide are dissolved in 50 ml of acetone and boiled under reflux for 4 h. After cooling, the precipitate is filtered off, washed with acetone and dried in a vacuum. 1-(2-trifluoromethylbenzimidazol-1-yl)-propanone is thus obtained.

Workup

  1. temperatureunder reflux for 4 h
  2. temperatureAfter cooling
  3. filtrationthe precipitate is filtered off
  4. washwashed with acetone
  5. customdried in a vacuum

Sources & evidence

ORD record
ord-f6c4ccca3bb84e3188e15f37b8c41c23
Source dataset
uspto-grants-2007_10
Patent number
US07279495B2

Reaction notes

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