反应详情

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperaziny]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 □L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was -washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

1. custompartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. customdried
3. concentrationconcentrated in vacuo
4. customThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]