Hexahydro-2-benzimidazolinone → 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)octahydro-2H-benzimidazol-2-one

HRID 1179643Notes

Reaction equation

HRID 1179643 reaction equation
I[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]4)[CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[NH:27]1[CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]2[NH:29][C:28]1=[O:36]>>[CH3:26][C:20]1[CH:19]=[CH:18][C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[N:13]2[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][C:4]3[CH:3]=[C:2]([N:27]4[CH:31]5[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]5[NH:29][C:28]4=[O:36])[CH:7]=[CH:6][CH:5]=3)[CH2:11][CH2:12]2)[N:21]=1

Participants

3

Reactant 2

HCID 101982Hexahydro-2-benzimidazolinoneHCID 574443555-{4-[2-(3-Iodophenyl)ethyl]-1-piperazinyl)2-methylquinoline

Product 1

HCID 574783841-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)octahydro-2H-benzimidazol-2-oneYield 100%

Procedure

The title compound was prepared in 100% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 5-{4-[2-(3-iodophenyl)ethyl]-1-piperazinyl}2-methylquinoline and octahydro-2H-benzimidazol-2-one.

Sources & evidence

ORD record
ord-1ee0b002ac864c76a8203ecb8bc5578a
Source dataset
uspto-grants-2007_10
Patent number
US07279481B2

Reaction notes

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