反应详情

To a solution of 4-aminophenol (3.08 g, 28.2 mmol) in dichloromethane (50 ml) were added cis/trans-4-tert-butyl-cyclohexanecarbonyl chloride (11.43 g, 56.4 mmol) and pyridine (4.56 ml, 56.4 mmol), while cooling the reaction mixture in an ice bath. After the addition was completed, the cooling bath was removed and stirring was continued overnight at room temperature. The solvent was removed by evaporation and the residue was dissolved in THF (300 ml). 6N NaOH (aq, 33 ml) was added and the mixture was stirred at room temperature overnight. The organic phase was removed by evaporation. Water (200 ml) was added and the solid material was collected by filtration, washed with water, dried in vacuo at 40° C. and dissolved in methanol (100 ml). A solution of KOH (2.4 g) in methanol (50 ml) was added. After stirring for 2 h at room temperature water (200 ml) was added and the organic phase was removed by evaporation. The aqueous phase was acidified with 1 N HCl and extracted with ethyl acetate (3×300 ml). The combined organic phases were washed with saturated sodium bicarbonate, dried, filtered and evaporated, yielding a pink oil, which was dried in vacuo at 40° C. The solid material was crystallised from ethyl acetate/heptane yielding the title compound (2.03 g, 26%, pink crystals). From the first aqueous extract a second portion of product was isolated by extraction with ethyl acetate (3×250 ml). The combined organic phases were washed with water (400 ml), saturated sodium bicarbonate (2×400 ml), dried, filtered and evaporated, yielding a pink thick oil. Crystallisation from ethyl acetate/heptane yielded a further amount of title compound (2.75 g, 35%).

1. temperaturewhile cooling the reaction mixture in an ice bath
2. additionAfter the addition
3. customthe cooling bath was removed
4. customThe solvent was removed by evaporation
5. dissolutionthe residue was dissolved in THF (300 ml)
6. addition6N NaOH (aq, 33 ml) was added
7. stirringthe mixture was stirred at room temperature overnight
8. customThe organic phase was removed by evaporation
9. additionWater (200 ml) was added
10. filtrationthe solid material was collected by filtration
11. washwashed with water
12. customdried in vacuo at 40° C.
13. dissolutiondissolved in methanol (100 ml)
14. additionA solution of KOH (2.4 g) in methanol (50 ml) was added
15. stirringAfter stirring for 2 h at room temperature water (200 ml)
16. additionwas added
17. customthe organic phase was removed by evaporation
18. extractionextracted with ethyl acetate (3×300 ml)
19. washThe combined organic phases were washed with saturated sodium bicarbonate
20. customdried
21. filtrationfiltered
22. customevaporated
23. customyielding a pink oil, which
24. customwas dried in vacuo at 40° C
25. customThe solid material was crystallised from ethyl acetate/heptane yielding the title compound (2.03 g, 26%, pink crystals)
26. extractionFrom the first aqueous extract a second portion of product
27. customwas isolated by extraction with ethyl acetate (3×250 ml)
28. washThe combined organic phases were washed with water (400 ml), saturated sodium bicarbonate (2×400 ml)
29. customdried
30. filtrationfiltered
31. customevaporated
32. customyielding a pink thick oil
33. customCrystallisation from ethyl acetate/heptane