反应详情

温度

190 °C

6′-Methoxy-4,4-dimethyl-4,5-dihydro-3H-[1,3′]bipyridinyl-2,6-dione (2.56 g, 10.3 m dissolved in a mixture of tetrahydrofuran and diethyl ether. HCl-gas was bubbled into the solution for 5 minutes. More diethyl ether was added and the white precipitate was collected by suction, washed twice with diethyl ether and heated in a kugelrohr apparatus at 190° C. for 15 minutes yielding the title compound (2.16 g, 89% yield) as a white solid.

1. customwas bubbled into the solution for 5 minutes
2. additionMore diethyl ether was added
3. customthe white precipitate was collected by suction
4. washwashed twice with diethyl ether