反应详情

4-Chlorobenzoyl chloride (1.75 g, 10.0 mmol) was added carefully to a stirred solution of 5-amino-2-methoxypyridine (1.24 g, 10.0 mmol) in dichloromethane (10 mL). After stirring overnight at room temperature, the solvent is evaporated in vacuo and the residue is heated in a pre-heated kugelrohr oven at 200° C. for 5-10 minutes under house-vacuum (around 20 mbar) yielding the title compound, which was used without further purification.

1. customthe solvent is evaporated in vacuo
2. temperaturethe residue is heated in a pre-heated kugelrohr oven at 200° C. for 5-10 minutes under house-vacuum (around 20 mbar)