Thionyl Chloride → HCID 22047722, compound

HRID 1179692Notes

Reaction equation

HRID 1179692 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][CH2:13][CH2:14][C:15]([Cl:17])=[O:16])=[O:11])=[CH:5][CH:4]=1.S(Cl)(Cl)=O>ClCCl>[ClH:17].[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:15](=[O:16])[CH2:14][CH2:13][CH2:12][C:10]2=[O:11])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22047823HCID 22047823, compound

Product 1

HCID 22047722HCID 22047722, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The crude 4-(6-methoxy-pyridin-3-ylcarbamoyl)-butyryl chloride was redissolved in dichloromethane (25 mL). Thionyl chloride (5.95 g, 50 mmol) was added and the solution was heated to reflux overnight. The solvent and excess thionyl chloride were evaporated in vacuo, yielding 6′-methoxy-4,5-dihydro-3H-[1,3′]bipyridinyl-2,6-dione hydrochloride, which was used without further purification.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvent and excess thionyl chloride were evaporated in vacuo

Sources & evidence

ORD record
ord-7adb2829e8b246f1808a7d9d416f69eb
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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