3-(4-Hydroxyphenoxy)-5-(trifluoromethyl)pyridine-2-carbonitrile → (4-Chloro-phenyl)-methyl-carbamic Acid 4-(2-cyano-5-trifluoromethyl-pyridin-3-yloxy)-phenyl Ester

HRID 1179745Notes

Reaction equation

HRID 1179745 reaction equation
[C:1]([C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:7][C:6]([C:17]([F:20])([F:19])[F:18])=[CH:5][N:4]=1)#[N:2].[I-].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]([CH3:38])[C:30](N2C=C[N+](C)=C2)=[O:31])=[CH:25][CH:24]=1>>[C:1]([C:3]1[C:8]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][C:30](=[O:31])[N:29]([C:26]3[CH:27]=[CH:28][C:23]([Cl:22])=[CH:24][CH:25]=3)[CH3:38])=[CH:14][CH:15]=2)=[CH:7][C:6]([C:17]([F:20])([F:18])[F:19])=[CH:5][N:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 43138633-(4-Hydroxyphenoxy)-5-(trifluoromethyl)pyridine-2-carbonitrileHCID 220477983-[(4-chlorophenyl)-methyl-carbamoyl]-1-methyl-3H-imidazol-1-ium iodide

Product 1

HCID 10151515(4-Chloro-phenyl)-methyl-carbamic Acid 4-(2-cyano-5-trifluoromethyl-pyridin-3-yloxy)-phenyl Ester

Procedure

The title compound was prepared from 4-(2-cyano-5-trifluoromethyl-pyridin-3-yloxy)-phenol and 3-[(4-chlorophenyl)-methyl-carbamoyl]-1-methyl-3H-imidazol-1-ium iodide. The crude product was purified by preparative HPLC (25%). HPLC-MS m/z=448.2 (M+1), Rt: 5.1 min.

Workup

  1. customThe crude product was purified by preparative HPLC (25%)

Sources & evidence

ORD record
ord-4281690ec91541e0b9f6d56d55a09ce7
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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