4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → HCID 23635401, compound

HRID 1179751Notes

Reaction equation

HRID 1179751 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[I-].[CH:20]1([N:26]([CH3:35])[C:27](N2C=C[N+](C)=C2)=[O:28])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(OCC)(=O)C.CCCCCCC>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][C:27](=[O:28])[N:26]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH3:35])=[CH:14][CH:15]=2)=[N:7][CH:8]=1

Participants

4

Reactant 2

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenolHCID 43145426HCID 43145426, compound

Product 1

HCID 23635401HCID 23635401, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 3-(cyclohexyl-methyl-carbamoyl)-1-methyl-3H-imidazol-1-ium iodide. The crude product was subjected to flash chromatography (ethyl acetate/heptane, 1:5) (80%, white crystals). HPLC-MS m/z=395.2 (M+1), Rt: 5.7 min.

Sources & evidence

ORD record
ord-6863598f58b941b2a44694687b49fd91
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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