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HRID 1179760作成日：2026年10月25日

4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → 3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester

https://huagongshe.com/reaction/1179760

反応式

関与物質

役割名称HCID仕込み量
反応物4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenolHCID 155241—
反応物3-methyl-1-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1H-imidazol-3-ium iodideHCID 22047918—
生成物3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl esterHCID 23635514—

反応手順

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 3-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-1-methyl-3H-imidazol-1-ium iodide. The crude product was recrystallized (ethanol) (53%). HPLC-MS m/z=415.2 (M+1), Rt: 5.3 min.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07279470B2
出典データセットuspto-grants-2007_10
ORD IDord-478889d52f73403380892516082929a6
出典メモuspto-grants-2007_10