Potassium Bromide → 4-(3,4-Dichloro-benzyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

HRID 1179960Notes

Reaction equation

HRID 1179960 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].[Cl:22][C:23]1[CH:24]=[C:25]([CH:33]=[CH:34][C:35]=1[Cl:36])[CH2:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.[K+].[Br-]>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:30]3[CH2:29][CH2:28][N:27]([CH2:26][C:25]4[CH:33]=[CH:34][C:35]([Cl:36])=[C:23]([Cl:22])[CH:24]=4)[CH2:32][CH2:31]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

4

Reactant 3

HCID 253877Potassium BromideHCID 27580741-(3,4-Dichlorobenzyl)piperazineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 574558344-(3,4-Dichloro-benzyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

Procedure

The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(3,4-dichloro-benzyl)-piperazine, yield 86%. White crystals, m.p. 229-230° C.; IR (KBr): ν 1717 (C═O) cm−1.

Sources & evidence

ORD record
ord-b9dbaac39d984928a998cc756aebaeba
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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