Potassium Bromide → HCID 69519682, compound

HRID 1179963Notes

Reaction equation

HRID 1179963 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].[Cl:22][C:23]1[CH:24]=[CH:25][C:26]([CH3:35])=[C:27]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:28]=1.[K+].[Br-]>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:32]3[CH2:31][CH2:30][N:29]([C:27]4[CH:28]=[C:23]([Cl:22])[CH:24]=[CH:25][C:26]=4[CH3:35])[CH2:34][CH2:33]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

4

Reactant 3

HCID 253877Potassium BromideHCID 693767N-(5-Chloro-2-methylphenyl)piperazineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 69519682HCID 69519682, compound

Procedure

The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(5-chloro-2-methyl-phenyl)-piperazine The crude product was converted to the free base, yield 26%. White crystals; HPLC-MS:m/z=492(M+H) at Rt=5.5 min.; IR (KBr): ν 1722 (C═O) cm−1.

Sources & evidence

ORD record
ord-6cc6230f56934c2f8600f94240689b4d
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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