4-(4,4-Dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate → 4-Pyridin-3-ylmethyl-piperazine-1-carboxylic acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester

HRID 1179971Notes

Reaction equation

HRID 1179971 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[CH2:15][C:14]([CH3:19])([CH3:18])[CH2:13][C:12]2=[O:20])=[CH:7][CH:6]=1)=[O:3].Cl.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:23]=1>>[CH3:18][C:14]1([CH3:19])[CH2:15][C:16](=[O:17])[N:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:32]3[CH2:33][CH2:34][N:29]([CH2:28][C:24]4[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=4)[CH2:30][CH2:31]3)=[O:3])=[CH:6][CH:7]=2)[C:12](=[O:20])[CH2:13]1

Participants

3

Reactant 2

HCID 220478954-(4,4-Dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformateHCID 45074811Piperazine, 1-(3-pyridinylmethyl)-, hydrochloride (1:1)

Product 1

HCID 574557864-Pyridin-3-ylmethyl-piperazine-1-carboxylic acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester

Procedure

The title compound was prepared from 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate and 1-pyridin-3-ylmethyl-piperazine, hydrochloride, preparative HPLC (Method C) (75%, colourless oil). HPLC-MS m/z=437.2 (M+1), Rt: 1.70 min.

Sources & evidence

ORD record
ord-3bd63e1d99be4d7794c21a987e14aed5
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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